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Methadone is a potent synthetic analgesic that works as a complete µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a complete MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins thru the discharge of neurotransmitters concerned in pain transmission.
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